Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men


Kelly, T., Yang, W., Chen, C. S., Reynolds, K. & He, J. Global burden of obesity in 2005 and projections to 2030. Int. J. Obes. 32(9), 1431–1437 (2008).

Article 
CAS 

Google Scholar 

Shaw, J. E., Sicree, R. A. & Zimmet, P. Z. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 87, 4–14 (2010).

Article 
CAS 
PubMed 

Google Scholar 

Cai, Q. et al. Obesity and COVID-19 severity in a designated hospital in Shenzhen, China. Diabetes Care 43(7), 1392–1398 (2020).

Article 
CAS 
PubMed 

Google Scholar 

Lynch, C. J. & Adams, S. H. Banched-chain amino acids in metabolic signalling and Insulin resistance. Nat. Rev. Endocrinol. 10(12), 723–736 (2014).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Wang, T. J. et al. Metabolite profiles and the risk of developing diabetes. Nat. Med. 17(4), 448–453 (2011).

Article 
PubMed 
PubMed Central 

Google Scholar 

Biswas, D. et al. Branched-chain ketoacid overload inhibits insulin action in the muscle. J. Biol. Chem. 295(46), 15597–15621. https://doi.org/10.1074/jbc.RA120.013121 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Tricò, D. et al. Elevated a-hydroxybutyrate and branched-chain amino acid levels predict deterioration of glycemic control in adolescents. J. Clin. Endocrinol. Metab. 102(7), 2473–2481 (2017).

Article 
PubMed 
PubMed Central 

Google Scholar 

White, P. J. et al. Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export. Mol. Metab. 5(7), 538–551. https://doi.org/10.1016/j.molmet.2016.04.006 (2016).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

White, P. J. et al. The BCKDH kinase and phosphatase…



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