Urinalysis Interpretation Explained Clearly – Glucose & Ketones in Urine

okay well therefore welcomed another MedCramlecture we’re going to talk about your analysis again and this time we’re gonnago into with the urinalysis of glucose ketones bilirubin urobilinogen andspecific seriousnes with respect to the urine okay let’s get started withglucose we use a peroxide procedure which will become important later so we useperoxides to measure glucose a peroxide action and the thing that you shouldknow that’s important is that when blood goes to the nephron there is a barrierthere in the nephron that is preventing glucose from being spilled into Bowman’scapsule and the proximal convoluted tubuleso if you can kind of imagine a dike with a wall and there is water so long as thewater doesn’t go over that damn wall there won’t be spillage over it that’sthe same analogy that we use with glucose and the list that you shouldknow for glucose is called the TM which stands for the transport maximum and inthis case that number is 180 micrograms per deciliter which meant that if theglucose concentration is greater than 180 milligrams per deciliter then therecould be spillage of glucose into the urine but if it is less than 180 milligrams per deciliter there should not be now if you do get that you’regonna have glucose that’s gonna be found in the urine and that has the effect ofdrawing in fluid because of its osmotic principle and you’re gonna get anosmotic diuresis but we’ll talk about that so again remember peroxidase andalso 180 milligrams per deciliter okay so what you’re gonna realise on a test on aurine test it’s either good to be negative or it’s going to be positiveand stages of positivity as we spoke before there is a way to make thisthing a incorrect negative and so you have to be careful that if the patient istaking high levels of vitamin C that can mayglucose even though there is glucose in the urine it could make it inspect negativeso there are things that can metabolize the vitamin C’s so you don’t get thosefalse negatives just so you’re aware in terms of positive you could have a traceyou can have a 1 plus a 2 plus a 3 plus and a 4 plus and these generally areassociated with approximately 100 milligrams per deciliter 250 500 athousand and up to 2,000 milligrams per deciliter in the urine okay so you couldget quite a bit of spillage of glucose in the urine okay so what does this meanyou interpret a positive glucose going on what does that mean there’s two possibilitiesusing our resemblance either you’ve got a bad wall okay that means that the damnwall is not holding back the sea and it’s spilling out or you’ve got spilloverokay so the bad wall is much more rare andthe spillover is much more common so let’s talk about the bad wall first thisis sometimes known as fan Kony’s condition with Vanko knee syndrome youhave a problem with reabsorption at the proximal convoluted tubules so you alsosee dumping of phosphate you’ll too watch dropping of uric battery-acid you’ll likewise seedumping of bicarbonate now if you remember if you don’t reabsorbbicarbonate well at the proximal convoluted tubule this is known as arenal tubular acidosis sort 2 okay and that gets into the pH and then of coursethe other thing that you see that comes dropped our amino acids now what arethings that can cause this Vanko knee syndrome well it could have somethingcalled several myeloma that is a cancerous illnes where you have plasmacells that’s overpopulate all the things that could be used to do this would be heavy metalsother things that could be used to do this would be prescriptions for example 10 of therewhich is an HIV medication chemo therapeutic negotiators likecisplatin can do it another medication that’s used in mood agitations that’svpa or valproic acid and then antibiotic which is used routinely isaminoglycosides so that would be like gentamicin tobramycin amikacin so immunoclyde’s can do this so all of these campaigns can cause the Fanconi syndromewhere we have a bad wall so in terms of spillover though where the wall is finebut you just have too much glucose in the blood the biggest one there you gotto know about is diabetes and of course you can have category 1 you can have sort 2you could have even gestational diabetes that could do it and anything basicallythat will increase your blood glucose for instance Cushing’s disease thatcould do it and that list leads jolly deep so those are the causes of glucosein the urine okay let’s vary up the dye a little let’s talk aboutketones so ketones in the urine it’s not typically as helpful as serum ketones nowthat those are more available so this is kind of an older test the way that thoseare checked for is something that you should know called the Nitro pro sidetest so what are the major reasons why somebody would have ketones in theirurine one of them is alcohol so alcoholic ketosis another one would beof course DKA which is diabetic ketoacidosis and then finally the lastone would be starvation ketoacidosis so what are ketones exclusively well thething that you’ve got to remember is in the cadre you’ve got the nucleus ofcourse but you’ve got these mitochondria all throughout and in the mitochondriainside them precisely are where fatty battery-acids get transported into the matrix ofthe mitochondria where something called beta oxidation results and beta oxidationtakes fatty battery-acids and changes them into acetic awaywhich are two carbon parts so these two carbon gangs if there’s a good deal of thisfatty acid metamorphosi into two carbon divisions a good deal of battery-acids crowded Kawaibecomes available and commonly that acetic away as you already know shouldgo into the krebs cycle but if there’s too much of it around and the krebscycle can’t be dealt with then they start to coalesce with each other and so if youhave this a steel Kawai which examines reasonably like this and you bind thesetogether you’re going to get things like acetoacetate and beta-hydroxybutyrate and acetone if you have two of theseyou’re going to make one acetoacetate and what does the COS state look like itlooks like this there’s one two three four carbonsnow acetoacetate can be proselytized and goes back and forth tobeta-hydroxybutyrate to look like this and as you can see here we have acarbonyl group being reduced to a hydroxy group and so because this isbeing reduced something has to be oxidized and that’s where you take and aD H and you oxidize it to n a D+ so you can get beta-hydroxybutyrate you can getacetoacetate of course what you can do is you could simply really chop off theco2 and then what you would get then is simply acetone which you breathe off sowhen you do the nitroprusside measure that are searching for specific acetoacetate andthe acces it does that is through this nitroprusside reaction which involvesnitro for a cyanide which turns it a neat purplish blue-blooded and that’s why we’rekind of writing it in blue-blooded here and what the hell is you getso with ketones you’re either going to get a negative or a positive and if youget a negative or positive you’re gonna get this violet colorthat’s going to turn the ketones positive but there’s also differentlevels of positive there’s tracing there’s 1+ 2+ 3++ 4+ and so for mark thatworks out to be about 5 milligrams per deciliter 1+ is 15 2+ is 43+ is 80 +4+ finally is about 160 or more thing now that you should know is that ifketones are positive you really should be checking them in the serum

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